4-(4-(Trifluoromethyl)phenoxy)benzoic acid → 2-{[(2S)-3-[4-(Difluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoyl]amino}ethyl acetate

Participants

Role	Name	HCID	Charge
Reactant	4-(4-(Trifluoromethyl)phenoxy)benzoic acid	HCID 3673481	—
Reactant	2-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate	HCID 69016365	—
Product	2-{[(2S)-3-[4-(Difluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoyl]amino}ethyl acetate	HCID 69018216	—

Reaction Steps

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(difluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-[4-(trifluoromethyl)phenoxy]benzoic acid used in Example 41 (41a) to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08344029B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-ad4357d60e2f4d98beba874674887205
Source note	uspto-grants-2013_01