2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetate → 2-({(2S)-2-({4-[4-(Trifluoromethyl)phenoxy]benzoyl}amino)-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetate

HRID 1799277Notes

Reaction equation

HRID 1799277 reaction equation
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH2:21])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].FC(F)(F)[C:25]1([CH:40]=[CH:39][CH:38]=[CH:37][CH2:36]1)[O:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([OH:33])=O)=[CH:29][CH:28]=1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH:21][C:31](=[O:33])[C:30]1[CH:29]=[CH:28][C:27]([O:26][C:25]2[CH:36]=[CH:37][C:38]([C:17]([F:20])([F:19])[F:18])=[CH:39][CH:40]=2)=[CH:35][CH:34]=1)[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:15][CH:16]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 690178742-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetateHCID 690195904-[1-(Trifluoromethyl)phenoxy]benzoic acid

Product 1

HCID 866365312-({(2S)-2-({4-[4-(Trifluoromethyl)phenoxy]benzoyl}amino)-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetate

Procedure

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetate and 4-[1-(trifluoromethyl)phenoxy]benzoic acid used in Example 41 (41a) to give the title compound.

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-39824624b02a42309c5f8df1a846a58a
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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