Methylparaben → 4-(4,4,4-Trifluorobutoxy)benzoic acid

HRID 1799285Notes

Reaction equation

HRID 1799285 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][CH:3]=1.[F:12][C:13]([F:19])([F:18])[CH2:14][CH2:15][CH2:16]O>>[F:12][C:13]([F:19])([F:18])[CH2:14][CH2:15][CH2:16][O:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7456MethylparabenHCID 1363074,4,4-Trifluorobutan-1-ol

Product 1

HCID 223614014-(4,4,4-Trifluorobutoxy)benzoic acidYield 66.6%

Procedure

A reaction similar to that described in Example 1 (1a) was conducted using methyl 4-hydroxybenzoate (1.19 g) and 4,4,4-trifluorobutan-1-ol (1.00 g) to give 1.29 g of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-c012a4b035594484be09f2e4cb26c3a7
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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