4-(4,4,4-Trifluorobutoxy)benzoic acid → 2-{[4-(4,4,4-Trifluorobutoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid

HRID 1799286Notes

Reaction equation

HRID 1799286 reaction equation
[F:1][C:2]([F:17])([F:16])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.Cl.[NH2:19][CH:20]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][C:32]([F:35])([F:34])[F:33])=[CH:27][CH:26]=1)[C:21]([OH:23])=[O:22]>>[F:16][C:2]([F:1])([F:17])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([NH:19][CH:20]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([O:31][C:32]([F:33])([F:34])[F:35])=[CH:29][CH:30]=2)[C:21]([OH:23])=[O:22])=[O:13])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 223614014-(4,4,4-Trifluorobutoxy)benzoic acidHCID 226033402-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride

Product 1

HCID 780686222-{[4-(4,4,4-Trifluorobutoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acidYield 95%

Procedure

A reaction similar to that described in Example 70 (70a) was conducted using 4-(4,4,4-trifluorobutoxy)benzoic acid (6.21 g) prepared in Example 81 (81a) and 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride (7.20 g) prepared in Reference Example 2 to give 11.4 g of the title compound (white powder).

Workup

  1. customA reaction similar to
  2. customprepared in Reference Example 2

Sources & evidence

ORD record
ord-3d24bff01c6b4d958910a9ee0312b3a9
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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