Ethanolamine → 2-Fluoro-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide

HRID 1799291Notes

Reaction equation

HRID 1799291 reaction equation
[F:1][C:2]1[CH:26]=[C:25]([O:27][CH2:28][CH2:29][C:30]([F:33])([F:32])[F:31])[CH:24]=[CH:23][C:3]=1[C:4]([NH:6][CH:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=1)[C:8]([OH:10])=O)=[O:5].[NH2:34][CH2:35][CH2:36][OH:37]>>[F:1][C:2]1[CH:26]=[C:25]([O:27][CH2:28][CH2:29][C:30]([F:33])([F:32])[F:31])[CH:24]=[CH:23][C:3]=1[C:4]([NH:6][CH:7]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][C:19]([F:21])([F:20])[F:22])=[CH:16][CH:17]=1)[C:8]([NH:34][CH2:35][CH2:36][OH:37])=[O:10])=[O:5]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 876576752-{[2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid

Product 1

HCID 579720832-Fluoro-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide

Procedure

A reaction similar to that described in Example 32 (32c) was conducted using 2-{[2-fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid (145 mg) prepared in Example 84 (84b) and 2-aminoethanol (22 μL) to give 128 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-3fef8f3f8277431181fc58437f95bbfa
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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