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HRID 1799291作成日：2026年10月25日

Ethanolamine → 2-Fluoro-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide

https://huagongshe.com/reaction/1799291

反応式

関与物質

役割名称HCID仕込み量
反応物EthanolamineHCID 700—
反応物2-{[2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acidHCID 87657675—
生成物2-Fluoro-n-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamideHCID 57972083—

反応手順

A reaction similar to that described in Example 32 (32c) was conducted using 2-{[2-fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid (145 mg) prepared in Example 84 (84b) and 2-aminoethanol (22 μL) to give 128 mg of the title compound (white powder).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08344029B2
出典データセットuspto-grants-2013_01
ORD IDord-3fef8f3f8277431181fc58437f95bbfa
出典メモuspto-grants-2013_01