Methylamine → HCID 57972113, compound

HRID 1799292Notes

Reaction equation

HRID 1799292 reaction equation
[F:1][C:2]([F:36])([F:35])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([NH:15][C:16](=[O:34])[C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[CH:19][CH:18]=2)[C:12](O)=[O:13])=[CH:6][CH:5]=1.[CH3:37][NH2:38]>>[CH3:37][NH:38][C:12](=[O:13])[CH:11]([NH:15][C:16](=[O:34])[C:17]1[CH:22]=[CH:21][C:20]([O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:26][CH:25]=2)=[CH:19][CH:18]=1)[CH2:10][C:7]1[CH:8]=[CH:9][C:4]([O:3][C:2]([F:35])([F:36])[F:1])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 78068621HCID 78068621, compound

Product 1

HCID 57972113HCID 57972113, compound

Procedure

A reaction similar to that described in Example 32 (32c) was conducted using 3-[4-(trifluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoic acid (720 mg) prepared in Example 88 (88a) and methylamine (798 μL, 2 M methanol solution) to give 330 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-1891a4aa1ffb4dcbbf5dc957b036ca8a
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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