2-Mercaptoethanol → HCID 18965738, compound

HRID 1799354Notes

Reaction equation

HRID 1799354 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][S:8][C:9]1[CH:14]=CC=CN=1.SCC[OH:18]>N1C=CC=CC=1.CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][S:8][CH:9]([OH:18])[CH3:14]

Participants

4

Reactant 2

HCID 15672-MercaptoethanolHCID 650932,2'-Dipyridyl disulfide

Product 1

HCID 18965738HCID 18965738, compound

Reagents, catalysts & solvents 1

HCID 22021344Pyridine methanolSolvent

Procedure

2.25 g of bis(2-pyridyl)disulfide are dissolved in 100 ml of pyridine:methanol (1:99). β-mercaptoethanol (700 μl, 1 eq.) is added dropwise to the solution. An immediate yellow color is observed. The medium is stirred overnight. The following day, starting product is no longer observed, and the solution is evaporated. The residue is passed over two silica columns, so as to obtain 770 mg of the expected product (column prepared with dichloromethane with a slight ethyl acetate gradient). Only the cleanest fractions are evaporated.

Workup

  1. customthe solution is evaporated

Sources & evidence

ORD record
ord-77ca2d5049e8493cbd14ad0ff0e1049d
Source dataset
uspto-grants-2013_01
Patent number
US08344082B2

Reaction notes

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