2-Mercaptoethanol → HCID 18965738, compound

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Reaction Steps

2.25 g of bis(2-pyridyl)disulfide are dissolved in 100 ml of pyridine:methanol (1:99). β-mercaptoethanol (700 μl, 1 eq.) is added dropwise to the solution. An immediate yellow color is observed. The medium is stirred overnight. The following day, starting product is no longer observed, and the solution is evaporated. The residue is passed over two silica columns, so as to obtain 770 mg of the expected product (column prepared with dichloromethane with a slight ethyl acetate gradient). Only the cleanest fractions are evaporated.

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