N-(2-adamantyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]-5-tert-butyl-pyrazole-4-carboxamide → Ethyl 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]-2-(trifluoromethyl)benzoate

HRID 1799432Notes

Reaction equation

HRID 1799432 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:23]3[CH:28]=[CH:27][C:26](Cl)=[C:25]([C:30]([F:33])([F:32])[F:31])[CH:24]=3)[C:18]=1[C:19]([CH3:22])([CH3:21])[CH3:20])=[O:13])[CH2:8]2.C12CC3CC(CC(C3)C1NC(C1C=NN(C3C=CC([C:60]([O:62][CH2:63][CH3:64])=[O:61])=CC=3C)C=1C(C)(C)C)=O)C2>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:23]3[CH:28]=[CH:27][C:26]([C:60]([O:62][CH2:63][CH3:64])=[O:61])=[C:25]([C:30]([F:33])([F:32])[F:31])[CH:24]=3)[C:18]=1[C:19]([CH3:22])([CH3:21])[CH3:20])=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 59516137N-(2-adamantyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]-5-tert-butyl-pyrazole-4-carboxamide2×HCID 59516141HCID 59516141, compound

Product 1

HCID 59516069Ethyl 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]-2-(trifluoromethyl)benzoate

Procedure

Ethyl 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]-2-(trifluoromethyl)benzoate was prepared from N-(2-adamantyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]-5-tert-butyl-pyrazole-4-carboxamide (Intermediate #118) by the same process used for Intermediate #113.

Sources & evidence

ORD record
ord-f88df5ad07e94244adbd179a4b9b6164
Source dataset
uspto-grants-2013_01
Patent number
US08344016B2

Reaction notes

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