反应详情

温度

100 °C

Potassium hydroxide (10.7 g) was heated to 100° C., and dissolved in isobutanol (15 mL). An isobutanol (25 mL) solution of 1-ethoxycarbonyl-4-(4-trifluoromethoxyphenoxy)piperidine (12.03 g) was dropwise added thereto while noticing generation of carbon dioxide gas. After the dropwise addition, the mixture was heated and stirred at 100° C. for 2 hours; then the solvent was concentrated; and toluene (40 mL) was added to the obtained residue. The toluene solution was washed with water (40 mL×2), and then the solvent was concentrated under reduced pressure to obtain a target compound as a light orange solid substance. The yield amount was 5.73 g (98% based on trifluoromethoxyphenol).

1. additionAfter the dropwise addition
2. temperaturethe mixture was heated
3. concentrationthen the solvent was concentrated
4. additionand toluene (40 mL) was added to the obtained residue
5. washThe toluene solution was washed with water (40 mL×2)
6. concentrationthe solvent was concentrated under reduced pressure