Water → HCID 59615778, compound

Participants

Reaction Steps

As shown in step 2-ii of Scheme 2, compound 1003 (400 mg, 1.56 mmol) was stirred in hydrazine hydrate at 70° C. for 20 minutes. Water was added and the resulting precipitate was collected by filtration, washed with water, and dried under high vacuum to produce 4-methyl-5-(pyridin-3-ylethynyl)thiazol-2-amine (compound 1004), which was used in subsequent reactions as is.

Provenance & Evidence