Water → HCID 59615778, compound

HRID 1799522Notes

Reaction equation

HRID 1799522 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:15]C(=O)C)[S:5][C:6]=1[C:7]#[C:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1.O>O.NN>[CH3:1][C:2]1[N:3]=[C:4]([NH2:15])[S:5][C:6]=1[C:7]#[C:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 962WaterHCID 49847091HCID 49847091, compound

Product 1

HCID 59615778HCID 59615778, compound

Reagents, catalysts & solvents 1

HCID 24654Hydrazine hydrate (1:1)Solvent

Procedure

As shown in step 2-ii of Scheme 2, compound 1003 (400 mg, 1.56 mmol) was stirred in hydrazine hydrate at 70° C. for 20 minutes. Water was added and the resulting precipitate was collected by filtration, washed with water, and dried under high vacuum to produce 4-methyl-5-(pyridin-3-ylethynyl)thiazol-2-amine (compound 1004), which was used in subsequent reactions as is.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-d998334c298045fdb025f2138eee204d
Source dataset
uspto-grants-2013_01
Patent number
US08344153B2

Reaction notes

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