Ammonia → HCID 86652371, compound

HRID 1799560Notes

Reaction equation

HRID 1799560 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[CH:4][CH:3]=1.[OH:10][CH:11]([CH3:15])[C:12](O)=O.Cl.N>CO>[Cl:1][C:2]1[N:7]=[C:6]2[N:8]=[C:12]([CH:11]([OH:10])[CH3:15])[NH:9][C:5]2=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 612Lactic AcidHCID 106306156-Chloropyridine-2,3-diamine

Product 1

HCID 86652371HCID 86652371, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Chloropyridine-2,3-diamine (150 mg, 1.05 mmol) and 2-hydroxypropanoic acid (277 mg, 2.61 mmol) were heated to 110° C. for 4 hours. To the cooled mixture was then added 1 N hydrochloric acid, followed by 7N ammonia in methanol to neutralize the acid. The aqueous solution was then evaporated under reduced pressure and the resulting oil was purified via flash chromatography (silica, 0-3% methanol/ethyl acetate) to afford the title compound.

Workup

  1. customThe aqueous solution was then evaporated under reduced pressure
  2. customthe resulting oil was purified via flash chromatography (silica, 0-3% methanol/ethyl acetate)

Sources & evidence

ORD record
ord-a866e8de21c441c0804735d433d4d0e5
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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