Potassium Carbonate → 5-[4-(1-Hydroxy-1-methylethyl)phenyl]-2-[(2-methoxypyrido[3,2-d]pyrimidin-6-yl)amino]thiophene-3-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl	HCID 11155794	—
Reactant	6-Bromo-2-methoxypyrido[3,2-d]pyrimidine	HCID 46835289	—
Reactant	2-Amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide	HCID 59526212	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Product	5-[4-(1-Hydroxy-1-methylethyl)phenyl]-2-[(2-methoxypyrido[3,2-d]pyrimidin-6-yl)amino]thiophene-3-carboxamide	HCID 58216630	—

Reaction Steps

The title compound was prepared according to the general procedure in Example 30 (Method B) using 6-bromo-2-methoxypyrido[3,2-d]pyrimidine (48 mg, 0.20 mmol), 2-amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (50 mg, 0.20 mmol), potassium carbonate (31 mg, 0.22 mmol), X-Phos (49 mg, 0.10 mmol), and tris(dibenzylideneacetone)dipalladium (16 mg, 0.02 mmol) as the starting materials.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08344144B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-5a2b054071084a5e88e0057ca0e068ee
Source note	uspto-grants-2013_01