2-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-ol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(1-hydroxy-1-methylethyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide

HRID 1799583Notes

Reaction equation

HRID 1799583 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:14])([CH3:13])[CH3:12])[N:10]=2)[N:7]=1.[F:15][C:16]1[CH:21]=[C:20]([C:22]([OH:25])([CH3:24])[CH3:23])[CH:19]=[C:18]([F:26])[C:17]=1[C:27]1[S:31][C:30]([NH2:32])=[C:29]([C:33]([NH2:35])=[O:34])[CH:28]=1>>[F:15][C:16]1[CH:21]=[C:20]([C:22]([OH:25])([CH3:24])[CH3:23])[CH:19]=[C:18]([F:26])[C:17]=1[C:27]1[S:31][C:30]([NH:32][C:2]2[CH:3]=[CH:4][C:5]3[N:6]([CH:8]=[C:9]([C:11]([OH:14])([CH3:13])[CH3:12])[N:10]=3)[N:7]=2)=[C:29]([C:33]([NH2:35])=[O:34])[CH:28]=1

Participants

3

Reactant 2

HCID 582166502-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-olHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 445552955-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(1-hydroxy-1-methylethyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1, Step 5 using 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-ol (258 mg, 1.22 mmol) and 5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-amino-thiophene-3-carboxamide (90 mg, 0.31 mmol) as starting materials.

Sources & evidence

ORD record
ord-f3257f140ed34bc497b2e6f372c95a71
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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