HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-ol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(1-hydroxy-1-methylethyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-ol | HCID 58216650 | — |
| Reactant | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| Product | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(1-hydroxy-1-methylethyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide | HCID 44555295 | — |
Reaction Steps
The title compound was prepared as described in Example 1, Step 5 using 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-ol (258 mg, 1.22 mmol) and 5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-amino-thiophene-3-carboxamide (90 mg, 0.31 mmol) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344144B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-f3257f140ed34bc497b2e6f372c95a71 |
| Source note | uspto-grants-2013_01 |