Isopropanol → 6-Chloro-2-(furan-2-yl)imidazo[1,2-b]pyridazine

HRID 1799584Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1799584
Br[CH2:2][C:3]([C:5]1[O:6][CH:7]=[CH:8][CH:9]=1)=O.[Cl:10][C:11]1[N:16]=[N:15][C:14]([NH2:17])=[CH:13][CH:12]=1.C(Cl)(Cl)Cl.C(O)(C)C>O1CCOCC1.O>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:2]=[C:3]([C:5]3[O:6][CH:7]=[CH:8][CH:9]=3)[N:17]=2)[N:16]=1

Komponenten

7

Edukt 4

HCID 3776IsopropanolHCID 6212ChloroformHCID 216436-Amino-3-chloropyridazineHCID 27950762-Bromo-1-(furan-2-yl)ethan-1-one

Produkt 1

HCID 117461286-Chloro-2-(furan-2-yl)imidazo[1,2-b]pyridazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-1-(2-furyl)ethanone (220 mg, 1.16 mmol) and 6-chloropyridazin-3-amine (150 mg, 1.16 mmol) in dioxane (4 ml) was stirred at room temperature for 1.5 hours, and at 65° C. for 16 hours. The reaction mixture was then cooled to ambient temperature, diluted with 3:1 (chloroform:isopropanol) and water. The layers were separated and the organic layer was concentrated under reduced pressure. Silica gel chromatography (0-15% methanol in dichloromethane) afforded the title compound.

Aufarbeitung

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-77b86ddbb8dc4b2ea93310589e089a64
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344144B2

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