6-Chloro-2-(furan-2-yl)imidazo[1,2-b]pyridazine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(2-furyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide

HRID 1799585Notes

Reaction equation

HRID 1799585 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[O:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)[N:7]=1.[NH2:16][C:17]1[S:18][C:19]([C:25]2[C:30]([F:31])=[CH:29][C:28]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:27][C:26]=2[F:36])=[CH:20][C:21]=1[C:22]([NH2:24])=[O:23]>>[F:36][C:26]1[CH:27]=[C:28]([C:32]([OH:35])([CH3:34])[CH3:33])[CH:29]=[C:30]([F:31])[C:25]=1[C:19]1[S:18][C:17]([NH:16][C:2]2[CH:3]=[CH:4][C:5]3[N:6]([CH:8]=[C:9]([C:11]4[O:12][CH:13]=[CH:14][CH:15]=4)[N:10]=3)[N:7]=2)=[C:21]([C:22]([NH2:24])=[O:23])[CH:20]=1

Participants

3

Reactant 2

HCID 117461286-Chloro-2-(furan-2-yl)imidazo[1,2-b]pyridazineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 445527345-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(2-furyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1, Step 5 using 6-chloro-2-(2-furyl)imidazo[1,2-b]pyridazine (61.9 mg, 0.282 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide as starting materials.

Sources & evidence

ORD record
ord-41c2afc77898425d9fb26b3afb404af6
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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