ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate → Ethyl 6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)imidazo[1,2-b]pyridazine-2-carboxylate

HRID 1799586Notes

Reaction equation

HRID 1799586 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:10]=2)[N:7]=1.[NH2:16][C:17]1[S:18][C:19]([C:25]2[C:30]([F:31])=[CH:29][C:28]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:27][C:26]=2[F:36])=[CH:20][C:21]=1[C:22]([NH2:24])=[O:23]>>[NH2:24][C:22]([C:21]1[CH:20]=[C:19]([C:25]2[C:30]([F:31])=[CH:29][C:28]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:27][C:26]=2[F:36])[S:18][C:17]=1[NH:16][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:10]=2)[N:7]=1)=[O:23]

Participants

3

Reactant 2

HCID 2779714ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylateHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 58216619Ethyl 6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)imidazo[1,2-b]pyridazine-2-carboxylate

Procedure

The title compound was prepared as described in Example 1, Step 5 using ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (430 mg, 1.92 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (400 mg, 1.28 mmol) as starting materials.

Sources & evidence

ORD record
ord-8e0fab8611644fc9b92a9bd6b93c383c
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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