ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate → Ethyl 6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)imidazo[1,2-b]pyridazine-2-carboxylate

Participants

Reaction Steps

The title compound was prepared as described in Example 1, Step 5 using ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (430 mg, 1.92 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (400 mg, 1.28 mmol) as starting materials.

Provenance & Evidence