6-Chloro-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide → 6-({3-(Aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide

HRID 1799589Notes

Reaction equation

HRID 1799589 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][CH:14]([CH3:16])[CH3:15])=[O:12])[N:10]=2)[N:7]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[C:31]([F:32])=[CH:30][C:29]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:28][C:27]=2[F:37])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[NH2:25][C:23]([C:22]1[CH:21]=[C:20]([C:26]2[C:31]([F:32])=[CH:30][C:29]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:28][C:27]=2[F:37])[S:19][C:18]=1[NH:17][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][CH:14]([CH3:16])[CH3:15])=[O:12])[N:10]=2)[N:7]=1)=[O:24]

Participants

3

Reactant 2

HCID 582166346-Chloro-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamideHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 445529036-({3-(Aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide

Procedure

The title compound was prepared as described in Example 1, Step 5 using 6-chloro-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide (149 mg, 0.62 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (177 mg, 0.57 mmol) as starting materials.

Sources & evidence

ORD record
ord-04d195bef03249b8bf1034dd168442e1
Source dataset
uspto-grants-2013_01
Patent number
US08344144B2

Reaction notes

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