反应详情

The title compound, m/e=405.7 ([M−H]−), was produced in analogy with example 18, steps 1 to 4. Thus, phenol was alkylated in step 1 with 11-bromo-1-undecanol, leading to 11-phenoxy-undecan-1-ol, which was oxidized in step 2 to 11-phenoxy-undecanoic acid. This was coupled in step 3 with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride to produce (R)-4-dimethylamino-3-[11-phenoxy-undecanoylamino]-butyric acid benzyl ester, which was hydrogenated in step 4.