HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → HCID 66874106, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 11-Bromo-1-undecanol | HCID 74163 | — |
| Reactant | 11-Phenoxyundecanoic acid | HCID 81597 | — |
| Reactant | 11-Phenoxy-1-undecanol | HCID 11572502 | — |
| Reactant | (R)-benzyl 3-amino-4-(dimethylamino)butanoate dihydrochloride | HCID 46223507 | — |
| Product | HCID 66874106 | HCID 66874106 | — |
Reaction Steps
The title compound, m/e=405.7 ([M−H]−), was produced in analogy with example 18, steps 1 to 4. Thus, phenol was alkylated in step 1 with 11-bromo-1-undecanol, leading to 11-phenoxy-undecan-1-ol, which was oxidized in step 2 to 11-phenoxy-undecanoic acid. This was coupled in step 3 with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride to produce (R)-4-dimethylamino-3-[11-phenoxy-undecanoylamino]-butyric acid benzyl ester, which was hydrogenated in step 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344027B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-55bd7863525f44ccbd9d3d51e826be69 |
| Source note | uspto-grants-2013_01 |