Hydroxide → 2-(2,6-Dichloro-4-hydroxy-benzyl)-2-aza-spiro[4.5]decan-1-one

HRID 180027Notes

Reaction equation

HRID 180027 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([Cl:28])[c:12]([CH2:13][N:14]2[C:15](=[O:24])[C:16]3([CH2:17][CH2:18]2)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:25]([Cl:27])[cH:26]1.[CH3:29][CH2:30][O:31][C:32](=[O:33])[CH3:34].[OH-:35].[OH-:37].[Pd+2:36]>>[OH:8][c:9]1[cH:10][c:11]([Cl:28])[c:12]([CH2:13][N:14]2[C:15](=[O:24])[C:16]3([CH2:17][CH2:18]2)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:25]([Cl:27])[cH:26]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 671483482-(4-Benzyloxy-2,6-dichloro-benzyl)-2-aza-spiro[4.5]decan-1-one

Product 1

HCID 671480262-(2,6-Dichloro-4-hydroxy-benzyl)-2-aza-spiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-e1ae83487f024085a580d9a9230b5f28
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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