Water → N-{3-[(6-{[(4-methylphenyl)sulfonyl]amino}pyridin-3-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide

HRID 1800372Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:27])[C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=3)[CH:12]=[CH:13][CH:14]=2)=[CH:4][CH:3]=1.[CH3:28][C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1.O>N1C=CC=CC=1>[CH3:28][C:29]1[CH:34]=[CH:33][C:32]([S:35]([NH:1][C:2]2[N:7]=[CH:6][C:5]([O:8][C:9]3[CH:10]=[C:11]([NH:15][C:16](=[O:27])[C:17]4[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=4)[CH:12]=[CH:13][CH:14]=3)=[CH:4][CH:3]=2)(=[O:37])=[O:36])=[CH:31][CH:30]=1

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of N-{3-[(6-aminopyridin-3-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (2.00 g, 5.36 mmol) in pyridine (60 mL) was added 4-methylbenzenesulfonyl chloride (1.12 g, 5.89 mmol) under ice-cooling, and the mixture was stirred with heating at 80° C. for 2 days. After cooling the reaction mixture to room temperature, water (200 mL) was added, and the mixture was extracted with ethyl acetate (300 mL). The organic layer was washed with saturated brine (300 mL), and dried over anhydrous sodium sulfate. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (2.75 g, 99%) as a yellow oil. The obtained compound was used for the next reaction without further purification.

Workup

temperaturecooling
temperatureAfter cooling the reaction mixture to room temperature
extractionthe mixture was extracted with ethyl acetate (300 mL)
washThe organic layer was washed with saturated brine (300 mL)
dry with materialdried over anhydrous sodium sulfate
filtrationThe insoluble material was filtered off
concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record: ord-270dcd025627409a93adb462219142c1
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08344135B2

Reaction notes

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