反应详情

tert-Butyl(4-methylpiperazin-1-yl)acetate (3.50 g, 16.3 mmol) was suspended in 4N hydrogen chloride/1,4-dioxane (35 mL) solution, trifluoroacetic acid (60 mL) was added to give a solution, and the solution was stirred at room temperature for 4 hr. The reaction mixture was concentrated under reduced pressure, 4N hydrogen chloride/ethyl acetate (30 mL) was added to the obtained oily residue to give a suspension, and the suspension was stirred at room temperature for 2 hr. The obtained precipitate was collected by filtration, washed with ethyl acetate and diisopropyl ether on filter paper, and dried to give the title compound (3.33 g, 88%) as a colorless powder. The compound was used for the next reaction without further purification operation.

1. additionwas added
2. customto give a solution
3. concentrationThe reaction mixture was concentrated under reduced pressure, 4N hydrogen chloride/ethyl acetate (30 mL)
4. additionwas added to the obtained oily residue
5. customto give a suspension
6. stirringthe suspension was stirred at room temperature for 2 hr
7. filtrationThe obtained precipitate was collected by filtration
8. washwashed with ethyl acetate and diisopropyl ether
9. filtrationon filter paper
10. customdried