反应详情

To a solution of methyl 4-chloro-3-(1-cyano-1-methylethyl)benzoate (8.0 g, 34 mmol) in tetrahydrofuran (30 mL) were added lithium hydroxide.monohydrate (2.13 g, 51 mmol), methanol (100 mL) and water (5 mL), and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated under reduced pressure, and the residue was diluted with water (200 mL). 1N Hydrochloric acid was slowly added to the mixture to adjust the pH to 3. The precipitated white precipitate was collected by filtration, washed with water, and dried to give the title compound (7.4 g, 99%) as a white powder.

1. customThe solvent was evaporated under reduced pressure
2. additionthe residue was diluted with water (200 mL)
3. addition1N Hydrochloric acid was slowly added to the mixture
4. filtrationThe precipitated white precipitate was collected by filtration
5. washwashed with water
6. customdried