HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(Aminomethyl)-4-phenylpiperidin-1-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (1-Methyl-4-phenylpiperidin-4-yl)methanamine | HCID 343885 | — |
| Reactant | 2-((Tert-butyldimethylsilyl)oxy)acetaldehyde | HCID 4187788 | — |
| Product | 2-(4-(Aminomethyl)-4-phenylpiperidin-1-yl)ethanol | HCID 59264544 | — |
Reaction Steps
The title material was prepared as described for the synthesis of (1-methyl-4-phenylpiperidin-4-yl)methanamine (Example B above) in using 2-(tert-butyldimethylsilyloxy)acetaldehyde and by doing an acidic work-up (HCl 5N) after the reductive amination to remove the protecting group. LC/MS (M+H)+: 235. HPLC ret. time (Condition A): 0.143 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343999B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0c52ffc3cae54970bb73001171774112 |
| Source note | uspto-grants-2013_01 |