Isoindoline → HCID 59321360, compound

HRID 1800840Notes

Reaction equation

HRID 1800840 reaction equation
[F:1][C:2]1[C:3]([C:22]([OH:24])=O)=[N:4][CH:5]=[CH:6][C:7]=1[S:8][C:9]1[S:13][C:12]([NH:14][C:15]2[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][N:16]=2)=[N:11][CH:10]=1.[CH2:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][NH:26]1>>[F:1][C:2]1[C:3]([C:22]([N:26]2[CH2:27][C:28]3[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:25]2)=[O:24])=[N:4][CH:5]=[CH:6][C:7]=1[S:8][C:9]1[S:13][C:12]([NH:14][C:15]2[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][N:16]=2)=[N:11][CH:10]=1

Participants

3

Reactant 2

HCID 422478IsoindolineHCID 592003973-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid2×

Product 1

HCID 59321360HCID 59321360, compound

Procedure

Following the amide bond forming procedure given in example 37, 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid (intermediate B in example 1) and isoindoline were reacted to give the title compound. LC/MS (M+H)+: 464. Ret. time: 1.66 min. (Condition M); analytical HPLC Ret. time: 17.03 min (Condition N).

Workup

  1. customforming procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-13d61c0bf3804bee9ac1900a682e0d56
Source dataset
uspto-grants-2013_01
Patent number
US08343999B2

Reaction notes

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