Methyl 4-aminobenzoate → HCID 178498127, compound

HRID 1801252Notes

Reaction equation

HRID 1801252 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[CH:12]([C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][CH:29]=1)[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])=O>C(O)C>[CH3:9][O:8][C:6]([C:5]1[CH:4]=[CH:3][C:2](/[N:1]=[CH:12]/[C:14]2[CH:15]=[C:16]([CH:27]=[CH:28][CH:29]=2)[C:17]([O:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:18])=[CH:11][CH:10]=1)=[O:7]

Participants

4

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 23286083Benzyl 3-formylbenzoate

Product 1

HCID 178498127HCID 178498127, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of methyl 4-aminobenzoate (7.94 g, 52.5 mmol) in ethanol (100 mL) was added benzyl 3-formylbenzoate in ethanol (50 mL) and the resulting mixture was stirred at room temperature for 2 h. The white solid precipitated was collected by filtration and washed with ethanol, dried in vacuo (50° C.) to give 15.6 g of (E)-benzyl 3-((4-(methoxycarbonyl)phenylimino)methyl)benzoate as a white solid.

Workup

  1. customThe white solid precipitated
  2. filtrationwas collected by filtration
  3. washwashed with ethanol
  4. customdried in vacuo (50° C.)

Sources & evidence

ORD record
ord-926e191db5534e739a9d6227ecf3edde
Source dataset
uspto-grants-2013_01
Patent number
US08344137B2

Reaction notes

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