Hydrochloric Acid → HCID 178479621, compound

HRID 1801558Notes

Reaction equation

HRID 1801558 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[C:18]([OH:20])[N:17]=[C:16]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:15]=[C:16]([N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[N:17]=[C:18]([OH:20])[CH:19]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451770HCID 178451770, compound

Product 1

HCID 178479621HCID 178479621, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of 4-(6-hydroxy-2-piperidin-1-yl-pyrimidin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.05 mol) in 15% HCl in dioxane (100 mL) was stirred at reflux for 2 hours. After reaction was completed the mixture was cooled, precipitate was filtered, washed with dry ether and dried to obtain 6-piperidin-4-yl-2-piperidin-1-yl-pyrimidin-4-ol, hydrochloride salt (12 g, 81%).

Workup

  1. temperatureat reflux for 2 hours
  2. customAfter reaction
  3. temperaturewas cooled
  4. filtrationprecipitate was filtered
  5. washwashed with dry ether
  6. customdried

Sources & evidence

ORD record
ord-5faca1887a9f4798b5b2bbe3b8315991
Source dataset
uspto-grants-2013_01
Patent number
US08349833B2

Reaction notes

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