Acetic Acid → HCID 21927805, compound

HRID 1801626Notes

Reaction equation

HRID 1801626 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH:12]([C:16]([S:29]([CH3:32])(=O)=[O:30])([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([OH:15])=[O:14])[N:4]=1.C(O)(=O)C.OO>O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH:12]([C:16]([S:29]([CH3:32])=[O:30])([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([OH:15])=[O:14])[N:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 21927796HCID 21927796, compound

Product 1

HCID 21927805HCID 21927805, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.2 g (2.9 mmol) of 2-(4,6-dimethoxy-2-pyrimidinyloxy)-3-methylsulfonyl-3,3-diphenylpropionic acid were introduced into 15 ml of glacial acetic acid at 0° C. and 294 μl of 30% strength H2O2 were added dropwise. The mixture was stirred at room temperature overnight, poured into water, extracted with CH2Cl2 and washed with sodium thiosulfate solution and brine. After drying, 1 g of substance was isolated as a white foam.

Workup

  1. extractionextracted with CH2Cl2
  2. washwashed with sodium thiosulfate solution and brine
  3. customAfter drying
  4. custom1 g of substance was isolated as a white foam

Sources & evidence

ORD record
ord-a7e9242ec1cb4a9c8fdd77046f5c0a10
Source dataset
uspto-grants-2013_01
Patent number
US08349843B2

Reaction notes

Loading…