Ethanol hydrochloride → HCID 66885784, compound

HRID 1801653Notes

Reaction equation

HRID 1801653 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:29]=[C:28]5[C:23]([CH:24]=[CH:25][N:26]([CH2:31][CH3:32])[C:27]5=[O:30])=[CH:22][CH:21]=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:33]CCCOC1C=C2C(C=CN(CC)C2=O)=CC=1.C(O)C.Cl>C(OCC)(=O)C>[ClH:33].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:29]=[C:28]5[C:23]([CH:24]=[CH:25][N:26]([CH2:31][CH3:32])[C:27]5=[O:30])=[CH:22][CH:21]=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 21887872Ethanol hydrochlorideHCID 66885504HCID 66885504, compoundHCID 66885965HCID 66885965, compound

Product 1

HCID 66885784HCID 66885784, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By a similar method as in Example 1, 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-ethyl-2H-isoquinolin-1-one was prepared from 7-(3-chloropropoxy)-2-ethyl-2H-isoquinolin-1-one, and after it was made into an ethyl acetate solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from ethyl acetate and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-ethyl-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-fda59b5b87184fa29d1f7c505806f025
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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