Ethanol hydrochloride → HCID 66884976, compound

HRID 1801654Notes

Reaction equation

HRID 1801654 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]4[CH:29]=[CH:28][C:27]5[C:22](=[CH:23][C:24]([O:30][CH3:31])=[CH:25][CH:26]=5)[C:21]4=[O:32])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:33]CCCCN1C=CC2C(=CC(OC)=CC=2)C1=O.C(O)C.Cl>C(OCC)(=O)C>[ClH:33].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]4[CH:29]=[CH:28][C:27]5[C:22](=[CH:23][C:24]([O:30][CH3:31])=[CH:25][CH:26]=5)[C:21]4=[O:32])[CH2:14][CH2:15]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 21887872Ethanol hydrochlorideHCID 66884823HCID 66884823, compoundHCID 66885228HCID 66885228, compound

Product 1

HCID 66884976HCID 66884976, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By a similar method as in Example 1, 2-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl]-7-methoxy-2H-isoquinolin-1-one was prepared from 2-(4-chlorobutyl)-7-methoxy-2H-isoquinolin-1-one, and after it was made into an ethyl acetate solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from ethyl acetate and thereby 2-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl]-7-methoxy-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-a4b356d699f940c2a52047feea9ae0eb
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

Loading…