Hydrochloric Acid → 1-(Benzo(b)thiophen-4-yl)piperazine dihydrochloride

HRID 1801657Notes

Reaction equation

HRID 1801657 reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]4[CH:31]=[C:30]5[C:25]([CH:26]=[CH:27][C:28](=[O:32])[NH:29]5)=[CH:24][CH:23]=4)[CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO.ClCCl>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]4[CH:31]=[C:30]5[C:25]([CH:26]=[CH:27][C:28](=[O:32])[NH:29]5)=[CH:24][CH:23]=4)[CH2:15][CH2:16]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11978813Brexpiprazole

Product 1

HCID 668842111-(Benzo(b)thiophen-4-yl)piperazine dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

1N hydrochloric acid aqueous solution was added to a solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from 70% ethanol and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one hydrochloride was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 70% ethanol

Sources & evidence

ORD record
ord-257914e8ec5a4fcdbf1076e78289d1ef
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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