Methanesulfonic Acid → HCID 86654693, compound

HRID 1801668Notes

Reaction equation

HRID 1801668 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[S:6]1[CH:10]=[CH:9][C:8]2[C:11]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:34]=[C:33]5[C:28]([CH2:29][CH2:30][N:31]([CH3:36])[C:32]5=[O:35])=[CH:27][CH:26]=4)[CH2:17][CH2:16]3)=[CH:12][CH:13]=[CH:14][C:7]1=2>C(O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[S:6]1[CH:10]=[CH:9][C:8]2[C:11]([N:15]3[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:34]=[C:33]5[C:28]([CH2:29][CH2:30][N:31]([CH3:36])[C:32]5=[O:35])=[CH:27][CH:26]=4)[CH2:19][CH2:20]3)=[CH:12][CH:13]=[CH:14][C:7]1=2

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11978936HCID 11978936, compound

Product 1

HCID 86654693HCID 86654693, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methanesulfonic acid was added to an ethanol solution of 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one and the solvent was evaporated under reduced pressure. The residue was recrystallized from 80% ethanol and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one methanesulfonate was obtained in the form of pale yellow prism crystal.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 80% ethanol

Sources & evidence

ORD record
ord-c74d1c142a5140a0a62d8c7c867cdff5
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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