反应详情

9a (40 mg) was dissolved in pyridine (5 mL) at room temperature. 6-(Trifluoromethyl)nicotinoyl chloride (218 mg) was added. The mixture was stirred at room temperature for 24 h. After quenching with ice, the crude product was purified by column (26 g silica gel, RT Scientific) (CH2Cl2:MeOH=100:0 to 98:2) to give the 10a (43 mg).

1. customAfter quenching with ice
2. customthe crude product was purified by column (26 g silica gel, RT Scientific) (CH2Cl2:MeOH=100:0 to 98:2)