HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Trifluoromethyl)nicotinoyl chloride → 6-(Trifluoromethyl)-N-(5-(2,3,4,5-tetrahydro-2,4-dioxo-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidin-6-yl)pyridin-2-yl)-N-(2-methoxyethyl)pyridin-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Trifluoromethyl)nicotinoyl chloride | HCID 2777557 | — |
| Reactant | 6-(6-(2-methoxyethylamino)pyridin-3-yl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione | HCID 59856635 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-(Trifluoromethyl)-N-(5-(2,3,4,5-tetrahydro-2,4-dioxo-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidin-6-yl)pyridin-2-yl)-N-(2-methoxyethyl)pyridin-3-carboxamide | HCID 24816256 | 74.2% |
Reaction Steps
9a (40 mg) was dissolved in pyridine (5 mL) at room temperature. 6-(Trifluoromethyl)nicotinoyl chloride (218 mg) was added. The mixture was stirred at room temperature for 24 h. After quenching with ice, the crude product was purified by column (26 g silica gel, RT Scientific) (CH2Cl2:MeOH=100:0 to 98:2) to give the 10a (43 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349848B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-90fa01c191fc4155ad294594f37b4e9b |
| Source note | uspto-grants-2013_01 |