2-Chloro-4-aminopyrimidine → 2-O-Methylcytosine

HRID 1801716Notes

Reaction equation

HRID 1801716 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][O-:10].[Na+]>CO>[CH3:9][O:10][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 3457522-Chloro-4-aminopyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 1606792-O-Methylcytosine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The solution of 2-chloropyrimidin-4-amine (1 mmol) and sodium methoxide (1.5 mmol) in 10 ml methanol was refluxed for 2 h, after removing of solvent, the residue was dissolved in CH2Cl2 and washed with water, dried over anhydrous NaSO4, concentrated in vacuo to give 2-methoxypyrimidin-4-amine.

Workup

  1. customafter removing of solvent
  2. dissolutionthe residue was dissolved in CH2Cl2
  3. washwashed with water
  4. dry with materialdried over anhydrous NaSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ee0ce7b2230145fdacbbde5e7bd45c5c
Source dataset
uspto-grants-2013_01
Patent number
US08349859B2

Reaction notes

Loading…