HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-aminopyrimidine → 2-O-Methylcytosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-aminopyrimidine | HCID 345752 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-O-Methylcytosine | HCID 160679 | — |
Reaction Steps
The solution of 2-chloropyrimidin-4-amine (1 mmol) and sodium methoxide (1.5 mmol) in 10 ml methanol was refluxed for 2 h, after removing of solvent, the residue was dissolved in CH2Cl2 and washed with water, dried over anhydrous NaSO4, concentrated in vacuo to give 2-methoxypyrimidin-4-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349859B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-ee0ce7b2230145fdacbbde5e7bd45c5c |
| Source note | uspto-grants-2013_01 |