反应详情

2,4-Dichloro-5-fluoropyrimidine (1 mmol) and 5-amino-2-methylindole (1.5 mmol) were dissolved in 3 ml CH3OH and 9 ml H2O. After the reaction mixture was stirred at room temperature for 1 h, it was diluted with H2O, acidified with 2N HCl, and sonicated. The reaction mixture was then filtered, washed with H2O and dried to give N-(2-chloro-5-fluoropyrimidin-4-yl)-2-methyl-1H-indol-5-amine in a yield of 78%.

1. customsonicated
2. filtrationThe reaction mixture was then filtered
3. washwashed with H2O
4. customdried