3-Methoxyaniline → HCID 178490983, compound

HRID 1801724Notes

Reaction equation

HRID 1801724 reaction equation
[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4](SC)[N:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([NH2:20])[CH:15]=1>C(O)CCCC>[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([NH:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH3:12])[CH:15]=2)[N:3]=1

Participants

4

Reactant 2

HCID 108243-MethoxyanilineHCID 178418413HCID 178418413, compound

Product 1

HCID 178490983HCID 178490983, compound

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Procedure

4-Hydroxy-2-(methylthio) pyrimidine-5-carbonitrile (3 mmol) and m-anisidine (3 mmol) in pentan-1-ol was refluxed for 40 h under nitrogen. The reaction mixture was concentrated in vacuo. The residue was washed with water and dried to afford 4-hydroxy-2-(3-methoxyphenylamino)pyrimidine-5-carbonitrile.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. washThe residue was washed with water
  3. customdried

Sources & evidence

ORD record
ord-0e1ab85460ab4fe09f6b34bc434ebca8
Source dataset
uspto-grants-2013_01
Patent number
US08349859B2

Reaction notes

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