Hydrochloric Acid → Topotecan Hydrochloride

Participants

Reaction Conditions

Reaction Steps

10 grams of topotecan base was suspended in 100 ml Methanol, and 2.4 ml HCl was added at 25-30° C. and stirred for 1 hour at 25-30° C., the suspension was further chilled to 10-15° C. and stirred for 1 hour at 10-15° C. and filtered, washed with 5 ml of methanol. The product was dried in vacuum at 25-30° C. for 5 hours, followed by drying at 30-35° C. for 36 hours to get 8.0 g of topotecan hydrochloride form A.

Provenance & Evidence