反应详情

温度

27.5 °C

10 grams of topotecan base was suspended in 100 ml Methanol, and 2.4 ml HCl was added at 25-30° C. and stirred for 1 hour at 25-30° C., the suspension was further chilled to 10-15° C. and stirred for 1 hour at 10-15° C. and filtered, washed with 5 ml of methanol. The product was dried in vacuum at 25-30° C. for 5 hours, followed by drying at 30-35° C. for 36 hours to get 8.0 g of topotecan hydrochloride form A.

1. temperaturethe suspension was further chilled to 10-15° C.
2. stirringstirred for 1 hour at 10-15° C.
3. filtrationfiltered
4. washwashed with 5 ml of methanol
5. customThe product was dried in vacuum at 25-30° C. for 5 hours
6. customby drying at 30-35° C. for 36 hours