Trifluoroacetic acid → Trifluoroacetic acid

HRID 1802053Notes

Reaction equation

HRID 1802053 reaction equation
[CH3:1][C:2]1[S:6][C:5]([NH:7]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[S:6][C:5]([NH2:7])=[CH:4][CH:3]=1.[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 716045tert-butyl N-(5-methylthiophen-2-yl)carbamate

Product 2

HCID 6422Trifluoroacetic acidHCID 113209235-methylthiophen-2-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 5-methylthiophen-2-ylcarbamate (0.825 g, 3.87 mmol) in CH2Cl2 (10 mL) and TFA (6 mL) wad stirred at room temperature for 20 h. Solvents was removed in vacuo to give 5-methylthiophen-2-amine as trifluoroacetic acid salt (0.870 g).

Workup

  1. customSolvents was removed in vacuo

Sources & evidence

ORD record
ord-f8067d3468024887b2b7ee94b5b69920
Source dataset
uspto-grants-2013_01
Patent number
US08349860B2

Reaction notes

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