Trifluoroacetic acid → HCID 178471901, compound

HRID 1802076Notes

Reaction equation

C(OC(=O)C(N)(C1C=CC2C(=CC=C(O[C@H]3CC[C@H](C(C)(C)C)CC3)C=2)N=1)C)C.C(O)(C(F)(F)F)=O.[CH2:37]([O:39][C:40](=[O:71])[C:41]([C:46]1[CH:55]=[CH:54][C:53]2[C:48](=[CH:49][CH:50]=[C:51]([O:60][C@H:61]3[CH2:66][CH2:65][C@H:64]([C:67]([CH3:70])([CH3:69])[CH3:68])[CH2:63][CH2:62]3)[C:52]=2[C:56]([F:59])([F:58])[F:57])[N:47]=1)([N+:43]([O-])=O)[CH3:42])[CH3:38]>>[CH2:37]([O:39][C:40](=[O:71])[C:41]([NH2:43])([C:46]1[CH:55]=[CH:54][C:53]2[C:48](=[CH:49][CH:50]=[C:51]([O:60][C@H:61]3[CH2:62][CH2:63][C@H:64]([C:67]([CH3:70])([CH3:69])[CH3:68])[CH2:65][CH2:66]3)[C:52]=2[C:56]([F:57])([F:59])[F:58])[N:47]=1)[CH3:42])[CH3:38]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 178470844HCID 178470844, compound

HCID 178471902HCID 178471902, compound

Product 1

HCID 178471901HCID 178471901, compoundYield 20%

Procedure

2-Amino-2-[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-quinolin-2-yl]-propionic acid ethyl ester was synthesized as per 2-amino-2-[6-(trans-4-tert-butyl-cyclohexyloxy)-quinolin-2-yl]-propionic acid ethyl ester (Example 17) in 20% yield (TFA salt) using 2-[6-(trans-4-tert-Butyl-cyclohexyloxy)-5-trifluoromethyl-quinolin-2-yl]-2-nitro-propionic acid ethyl ester as starting material.

Sources & evidence

ORD record: ord-5f64a6c506e743ccae2d923960b90ad0
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08349849B2

Reaction notes

Loading…