反应详情

A 1 L pressure vessel was charged 10% Pd—C, dry Enge1 hard (10:90, palladium:carbon black, 0.966 g, 0.000908 mol) under an atmosphere of nitrogen. The solution of 2-benzylamino-2-(6-benzyloxy-3,4-dihydro-naphthalen-2-yl)-propane-1,3-diol (23.75 g, 0.05716 mol) in ethanol (300 mL, 5 mol) and ethyl acetate (300 mL, 3 mol) was added under an atmosphere of nitrogen. The mixture was connected to a H2 line, flashed with 50 psi of H2 three times, then stirred under 50 psi of H2 for 6 hours. The mixture was continuously stirred under 50 psi of H2 overnight. Acetic acid (18.0 mL, 0.316 mol) was added and the mixture was stirred under 50 psi of H2 for 30 hours. 10% Pd—C, dry Engelhard (10:90, palladium:carbon black, 1.01 g, 0.000949 mol) suspended in 10 mL of EtOAc was added and the mixture was continuously stirred under 50 psi of H2 for 45 hours. The mixture was filtered through Celite, concentrated to 54 g. The material was dissolved in ethanol (300 mL, 5 mol) and acetic acid (10.0 mL, 0.176 mol). The resulted solution was added to a pressure hydrogenation flask charged with 10% Pd—C, dry Engelhard (10:90, palladium:carbon black, 2.10 g, 0.00197 mol) under an atmosphere of Nitrogen. The mixture was flashed with 50 psi of H2 three times then stirred under 50 psi of H2 for 3 days. Acetic acid (10.0 mL, 0.176 mol) was added and the mixture was continuously stirred under 50 psi of H2 for 24 more hours. The reaction mixture was released from the H2 pressure, filtered through Celite, concentrated and dried in high vacuum to give a crude product. The material was used for next step without further purification. 1H NMR (MeOD) δ: 6.84-6.99 (m, 1H), 6.43-6.61 (m, 2H), 3.62-3.88 (m, 4H), 2.55-2.94 (m, 4H), 2.17-2.35 (m, 1H), 1.91-2.11 (m, 1H), 1.68-1.82 (m, 1H). MS (M+1): 238.0.

1. dry with materialdry Enge1 hard (10:90, palladium:carbon black, 0.966 g, 0.000908 mol) under an atmosphere of nitrogen
2. stirringThe mixture was continuously stirred under 50 psi of H2 overnight
3. stirringthe mixture was stirred under 50 psi of H2 for 30 hours
4. dry with material10% Pd—C, dry Engelhard (10:90, palladium:carbon black, 1.01 g, 0.000949 mol)
5. additionwas added
6. stirringthe mixture was continuously stirred under 50 psi of H2 for 45 hours
7. filtrationThe mixture was filtered through Celite
8. concentrationconcentrated to 54 g
9. additionThe resulted solution was added to a pressure hydrogenation flask
10. dry with materialdry Engelhard (10:90, palladium:carbon black, 2.10 g, 0.00197 mol) under an atmosphere of Nitrogen
11. stirringthen stirred under 50 psi of H2 for 3 days
12. stirringthe mixture was continuously stirred under 50 psi of H2 for 24 more hours
13. filtrationfiltered through Celite
14. concentrationconcentrated
15. customdried in high vacuum