反应详情

温度

25 °C

A mixture of methyl 2-(tert-butoxycarbonylamino)-5-fluoroisonicotinate (1.80 g, 6.66 mmol) and hydrochloric acid (6N in ether, 40 ml, 240 mmol) is stirred for 20 hours at 25° C. The solvent is evaporated and the light brown slurry is diluted with ethyl acetate, cooled to 0° C. and adjusted to pH 8 with sat. aqueous sodium carbonate solution. The organic layer is washed with brine, dried with magnesium sulfate and the solvent is removed under reduced pressure affording methyl 2-amino-5-fluoroisonicotinate (932 mg, 82.2%) as a brown waxy solid. MS: m/z=171.0 (M+H+).

1. customThe solvent is evaporated
2. additionthe light brown slurry is diluted with ethyl acetate
3. temperaturecooled to 0° C.
4. washThe organic layer is washed with brine
5. dry with materialdried with magnesium sulfate
6. customthe solvent is removed under reduced pressure