反应详情

温度

25 °C

A mixture of tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate (252 mg, 767 μmol) and hydrochloric acid (5N in ether, 6 ml, 30.0 mmol) is stirred for 18 hours at 25° C. The mixture is adjusted to pH=ca 8 with sat. aqueous sodium carbonate solution and extracted twice with ethyl acetate, the organic layers are separated, dried with magnesium sulfate and the solvent is evaporated under reduced pressure affording 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-amine (175 mg, 100%) as a light yellow solid. Mp.: >250° C. MS: m/z=229.2 (M+H+).

1. extractionextracted twice with ethyl acetate
2. customthe organic layers are separated
3. dry with materialdried with magnesium sulfate
4. customthe solvent is evaporated under reduced pressure